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General anaesthesia boosts dementia risks for elderly 全身麻醉增加年長者失智風險

◎魏國金

General anaesthesia for the elderly boosts the risks of dementia by more than a third, according to a study by French doctors.

年長者全身麻醉將增加失智風險逾3分之1，法國醫師所做的研究指出。

Researchers led by Francois Sztark at the University of Bordeaux in southwestern France analysed data from a long-term study into cognitive decline covering 9300 elderly people in three French cities.

法國西南部波爾多大學專家史塔克領導的研究人員，對一項涵蓋法國3個城市、9300名年長者有關認知衰退的長期研究進行分析。

The volunteers - average age 75 - were interviewed when they were recruited into the study and then two, four, seven and 10 years afterwards.

這些平均年齡75歲的志願者在他們被招募參與研究時接受訪談，2、4、7和10年後再次受訪。

The data, which was released on Friday, showed a link between the onset of dementia and a general anaesthetic that had been administered two or three years before.

這份週五公布的資料顯示，失智的發病與2到3年前所做的全身麻醉有關。

Those who had received general anaesthesia were 35 per cent likelier to develop dementia symptoms by the next follow-up interview compared with counterparts who had not had general anaesthetic.

那些接受全身麻醉者到下次的後續訪談前，相較於沒有接受全身麻醉者，出現失智症狀的機率多出35％。

Previous work has already highlighted a condition called post-operative cognitive dysfunction, or POCD, in which an elderly patient who undergoes major surgery also goes into mental decline relatively soon afterward.

此前的研究成果已凸顯稱為「手術後認知功能障礙」或POCD的症狀，即經歷重大手術的年長病患，此後相對快速地也進入心智衰退狀態。

The reasons for this, though, are unclear. Some experiments suggest various anaesthetics inflame neural tissues, causing protein plaques and tangles to develop that are precursors of Alzheimer’s disease. （AFP） 儘管箇中原因不明，但若干實驗顯示，許多麻醉劑會讓神經組織發炎，引發蛋白斑塊與糾結的生成，這些是阿茲海默氏症的前兆。（法新社）

新聞辭典

follow-up︰可做名詞與形容詞，後續（的）。例句︰We still need more effective follow-up studies.（我們還需進行更有成效的後續研究。）

go into︰動詞片語，進入…狀態。例句︰She easily goes into a temper.（她易怒。）

inflame︰動詞，使發炎、使燃燒、使極度激動。例句︰His words inflamed her even more.（他的話語使她更加憤怒。）

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